Stefan Fruehauf,W. Jens Zeller,Gary Calandra's Novel Developments in Stem Cell Mobilization: Focus on CXCR4 PDF

By Stefan Fruehauf,W. Jens Zeller,Gary Calandra

lately the CXCR4/CXCL12-axis has been famous as one of many pivotal adhesion pathways during which hematopoietic stem cells are retained within the bone marrow. CXCR4 antagonists with varied chemical specification are being built. Pharmacology examine courses the best way to the rational improvement powerful antagonists. One antagonist, plerixafor, is clinically licensed now for stem telephone mobilization of lymphoma and myeloma sufferers. this permits sufferers to obtain very likely life-saving remedy which may now not were administered in a different way. via early medical stories it was once famous that CXCR4 antagonists additionally mobilize malignant hematopoetic cells, i.e. leukemia cells. In preclinical experiences a sensitization of mobilized leukemic cells to plain cytotoxic chemotherapy may be proven. scientific reviews are lower than means. CXCR4 antagonists are a thrilling new classification of compounds that are additionally hired for the mobilization of angiogenic cells or for the remedy of sturdy tumors. during this booklet a concise evaluate of the present prestige of information and destiny advancements can be presented.

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Novel Developments in Stem Cell Mobilization: Focus on CXCR4 by Stefan Fruehauf,W. Jens Zeller,Gary Calandra

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